Non-steroidal anti-inflammatory drugs - rating of good funds 2021

Nonteroidal anti-inflammatory drugs - rating

Non-steroidal anti-inflammatory preparations are used quite widely to suppress inflammatory processes in the body. NSAIDs are available in various form of release: pills, capsules, ointments. They possess three main properties: antipyretic, anti-inflammatory and painful.

The best non-steroid anti-inflammatory drug can only find a doctor, pushing out the individual characteristics of the patient. Self-medication in this case may be fraught with the development of serious adverse reactions or overdose. We offer to get acquainted with the list of drugs. The rating was developed on the basis of the ratio of price-quality, patient reviews and opinions of specialists.

How do NSAID work?

How to work NSAIDs

Nonteroids inhibit platelet aggregation. Therapeutic properties are explained by the blockade of the cyclooxygenase enzyme (COX-2), as well as a decrease in the synthesis of prostaglandin. According to experts, they influence the symptoms of the disease, but do not eliminate the cause of its occurrence. Therefore, we should not forget about the means by which the primary mechanisms for the development of pathology should be eliminated.

If the patient has the intolerance to the NSAID, then they are replaced with drugs of other categories. Often in such cases are used a combination of anti-inflammatory and painful agents.

In its anesthetics, they are used in the following cases:

  • with rheumatic pains;
  • with inflammatory diseases;
  • With degenerative processes in the body.

Also prescribed for irregular diseases, such as migraine and any inflammatory process. Widely used in fractures, dislocation and tension of ligaments.

As practice shows, it is impractical to replace one medicine for the other of the same group if an insufficient therapeutic effect is detected when taking. Dvu doubling can only lead to a clinically insignificant increase in exposure.

Possible side effects:

  • intestinal dysfunction;
  • internal hemorrhage;
  • gastric ulcer and duodenal intestine;
  • swelling of the lower extremities and face;
  • an increase in blood pressure;
  • Allergic reactions.

To reduce the risk of negative consequences, specialists when choosing a medication tools are trying to give preference to those possessed by selective action. According to doctors, these funds have a minimal negative impact on the digestive tract. In some cases, the NSAIDs can be taken in conjunction with anti-sized means, if necessary.

You can also avoid side effects when choosing the correct mode and dosage. It is recommended to take non-steroidal anti-inflammatory drugs with food.

There are certain rules for receiving NSAIDs:

  1. Capsules or tablets should be made with plenty of water (at least 200 ml). Thus, it is prevented by the destruction of the mucous membrane of the stomach.
  2. It is not recommended to take two different drugs on the same day. Otherwise, side effects may increase without increasing efficiency.
  3. Before taking medicines, you need to carefully read the instructions.

The key to successful treatment and lack of complications - preliminary consultation with the doctor. The specialist first conducts a survey and on the basis of the established diagnosis prescribes the most appropriate means.

Classification NSAID

Classification NSAID

Non-steroidal anti-inflammatory funds are classified depending on whether they are selective for COF-2 or not. Thus, on the one hand, there are non-selective NSAIDs, and on the other - selective COG-2.

Table - Conditional classification on 4 groups of action mechanism

Mechanism of action

Groups

Selective COF-1

Acetylsalicylic acid (low doses).

Non-selective Central Inhibitors

"Standard" NSAIDs.

Monsterly selective COF-2 inhibitors

Meloxico, nimesulide.

High-selective (specific) COF-2 inhibitors

Koksibi.

Alternative: chondroprotectors are prescribed if there are serious contraindications. They are also effective against articular pathologies and osteochondrosis, without providing internal organs and negative systems. Chondroprotectors reduce the need to use paracetamol and NSAIDs.

Non-steroidal anti-inflammatory drugs

Non-steroidal anti-inflammatory drugs

NSAIDs of the new generation are widely used in various fields of medicine as therapeutic agents. They are prescribed in the therapy of pathological processes in the joints of the joints, since the current and auxiliary components do not destroy the cartilage structures.

We offer a list of non-steroidal anti-inflammatory drugs of a new generation that possess the election action. They effectively cope with the tasks set, but they can cause adverse reactions. That is why preliminary consultation with the doctor is recommended. Without medical control to take the NSAIDs, you can not more than 3 days in a row.

№1 - "Ibuprofen" (Borisov Plant, Republic of Belarus)

Opens a list of non-steroidal anti-inflammatory drugs for joints. The phenylpropionic acid derivative is in the first place among the best NSAIDs. Tablets are used to treat all types of pain, including those that arise in the context of arthritis or arthrosis. According to the World Health Organization, this medicine is available worldwide and is considered one of the safest among aspirin, paracetamol, etc.

The active substance inhibits an enzyme, the so-called cyclooxygenase, which turns into prostaglandins and thromboxanes (substances that cause inflammation of muscle tissues). Reduces the release of such substances, which makes it effective to facilitate discomfort caused by inflammation.

Ibuprofen reduces the symptoms of fever and many types of pain: head, thorny, muscle, dentals, and those related to arthritis. Removes spasms that affect the lower part of the abdomen and are common in menstruation.

Ibuprofen Tablets covered with a shell 200 mg 50 pcs.

№2 - "Dolgit" (Dolorgiet, Germany)

Cream "Dolgit" is intended for outdoor use. Phenylpropionic acid derivative has an analgesic and anti-inflammatory effect.

The benefits of use are as follows:

  • Increases the volume of movement in the joints;
  • Eliminates the morning stiffness.

It is assigned as an anesthetics, which effectively copes with inflammatory processes.

Long cream for outdoor use 5% tube 100 g

№3 - Nooofen Express Forte (Reckitt Benckiser, Netherlands)

Capsules are prescribed with painful syndrome of various origin. Quickly copes with neuralgia, and also facilitates the state during menstruation. Used to relieve articular and muscle discomfort with influenza and cold. Designed for adults and children aged 12 years. It is unacceptable to use more than 3 pcs. (1200 mg) for 24 hours.

Contraindications: Allergies to ibuprofen or any other component that is part of. It is unacceptable to use with bronchial asthma, an ulcer of the stomach, perforation of intestines, severe hepatic, renal or heart failure. It is not recommended to take in the third trimester of pregnancy.

Nooofen Express Forte Capsules 400 mg 20 pcs.

№4 - "NAZ" (Dr. Reddy's Laboratories, India)

The main active substance is nimesulide. The active ingredient blocks the synthesis of prostaglandin, eliminating inflammation. Nimesulide in tablets in addition to the effect of analgesia has an antioxidant and anti-ethnic effect.

"NAZ" in a tablet form is assigned to relieve symptoms in osteoarthritis, bursite, tend little, rheumatism, neuralgia and Malgia, fever, as well as ankylosing spondyloarthritis. With it, muscle or vertebral pain decreases, the intensity of post-traumatic syndrome is reduced, the development of infectious lesions is blocked.

Nay Tablets 100 mg 30 pcs.Nonteroidal anti-inflammatory drugs - recipe

№5 - "Voltren Emulgel" (Novartis Pharma, Switzerland)

The preparation for local application contains diclofenac, which reduces discomfort and relieves inflammation. The emulsion in the form of a gel penetrates quickly into the skin, starting to act almost instantly.

Produced in the form of gel for outdoor use in tubes

50 g

(Price: 515 rubles) and 100 g (price: 769 rub.).

Appointed "Voltaren Emulgel" to adults and children aged 14 and older:

  • to remove the edema in injuries of soft tissues, tendons, muscular and articular structures;
  • with localized rheumatism, tend you, bursitis;
  • To facilitate the state with some forms of rheumatism.

It is recommended not to exceed the dose that is in question in the instructions for use, unless not written by the doctor.

Voltren Emulgel gel for outdoor use 2% 50 g

№6 - "Nimesil" (Berlin-Chemie / a. Menarini, Germany)

Granules for the preparation of suspension are widely used after surgery, in arthritis or other lesions of the musculoskeletal system, which are accompanied by a deterioration in well-being. Effectively eliminates fever, which can occur in infectious processes or for other reasons. "Nimesil" is an effective way to normalize the state of the joints and soft tissues. It is also prescribed for vascular, gynecological and urological disorders. Among other indications, degenerative and inflammatory processes of the musculoskeletal system should be selected.

It is forbidden to use in pediatrics if the doctor does not agree otherwise individually. The effect occurs almost instantly and lasts for 6 hours.

Nimesil granules for the preparation of suspension for reception inside 100 mg / 2 g of package 1 pc.

№7 - "Nimesulid" (Ozone Ltd., Republic of Macedonia)

It is shown in arthritis, trend and inflammatory processes, including after surgery, with gynecological and infectious diseases. In the course of past research, it was found that the drug is able to have an anesthetic effect pretty quickly - just over 20 minutes after use, so it is indispensable for the treatment of acute states. It is recommended to take after eating, drinking sufficient water.

Nimesulide Tablets 100 mg 20 pcs.

№8 - "Meloxico" (Vertex, Russia)

Designed to facilitate discomfort, reduction of sensitivity, inflammation and stiffness caused by osteoarthritis and rheumatoid arthritis. "Meloxicam" is shown to normalize the condition and elimination of rigidity caused by juvenile rheumatoid arthritis (found in childhood of children). Refers to the class of drugs known as NSAIDs. The current component stops the production of a substance that causes pain and inflammation.

Meloxico tablets 15 mg 20 pcs.

№9 - "Kaetonal Duo" (Lek d. D., Slovenia)

The antipyretic, anti-inflammatory and painful agent is characterized by a surgery with a slow release and prolonged effect. It is included in the list of the best non-steroidal anti-inflammatory drugs. After taking medication, it is absorbed quite well from the gastrointestinal tract (gastrointestinal tract). Bioavailability in total is at least 90%. About two hours after use, the maximum concentration is achieved.

Ketoprofen penetrates the synovial fluid, where it is preserved for at least 30 hours. The dissection of the medication occurs in the liver, removal through the kidneys.

Kaetonal Duo Capsules with modified release of 150 mg 30 pcs.6.jpg.

№10 - "Ketoprofen" (Synthesis of OJSC, Russia)

Gel removes the morning stiffness of the joints and causes the weakening of arthralgia. "Ketoprofen" is effective in muscle pain and post-traumatic lesions. Before starting therapy, alternative treatment options are considered. It is recommended to use the minimum possible efficient dosage and the shortest duration of therapy in accordance with the treaties of treatment.

Ketoprofen gel for outdoor use 5% tuba 30 g

№11 - "Diclofenak" (Synthesis of OJSC, Russia)

It is included in the list of non-steroidal anti-inflammatory drugs of the new generation. During therapy in rheumatic diseases, discomfort reduces discomfort in the joints (for example, in motion and in peace), reduces swelling and stiffness, which occurs in the morning. At the same time, it helps increase the range of motion during the disease of the joint. The gel for external use is indiscrutively oppressed by the enzymes of COF-1 and COG-2. Stable effect develops after 1-2 weeks of therapy.

Diclofenac Gel for Nursing Application 5% 100 g Synthesis

№12 - "Doluben Gel" (Merckle, Germany)

The gel contains an analgeling and anti-inflammatory active component of ibuprofen. Designed for the treatment of edema, inflammation of articular soft tissues (for example, mucous bags, tendons, tendon shells, ligaments and articular capsules). It can be applied in sports injuries, such as bruises, stretching, deformation.

The duration of treatment is determined by the doctor. With rheumatic diseases, as a rule, enough 3 weeks. In athletic and accidents, treatment can be up to 2 weeks.

Doluben gel for outdoor use tube 45 g

№13 - "Amelotex" (Ozone Ltd., Russia)

Gel is designed on the basis of meloxicam. Quickly relieves inflammation and discomfort, possessing chondroprotective properties. No negative effect on the cartilage tissue in the process of therapy is absent. The advantage is to increase the volume of movement. It is recommended to apply twice a day for 3-4 weeks.

Amelotex gel for outdoor use 1% tube 50 g

№14 - "Mobile" (Boehringer Ingelheim, Spain)

Completes the list of common NSAIDs for the treatment of joints. The solution for intramuscular administration contains meloxico. Refers to an enoloic acid derivative. Designed for starting therapy and short-term symptomatic treatment. With other NSAIDs simultaneously apply unacceptable.

Movied solution for intramuscular administration 15 mg / 1.5 ml ampoule 5 pcs.findings Non-steroidal anti-inflammatory drugs

After reading the list of tablets, gels and solutions of non-steroidal anti-inflammatory drugs, it can be concluded about the effectiveness and cost of medicines. But the last word should be behind the attending physician. It should be understood all the responsibility of the uncontrolled use of medicines.

Do not risk your health and engage in self-medication with nonsteroidal anti-inflammatory agents. To assign efficient and safe therapy, contact a specialist.

Literature:

https://www.rlsnet.ru/fg_index_id_211.htmhttpps://www.vidal.ru/drugs/clinic-group/157httpps://medi.ru/info/11573/https://www.vidal.ru/ DRUGS / CLINIC-GROUP / 151 When the drug Ketorol is prescribed

A group of non-steroidal anti-inflammatory drugs includes many items, among which Ketorol. It allows the pain of moderate severity with pain syndrome and reduce inflammation.

Content:

Out of issue of ketorol

Ketorol can be found in three dosage forms. Tablets for systemic treatment of pain. Most often, they are used during dental pain. Gel for outdoor use is suitable as local pain relief in joint pain. Injection for intramuscular administration is prescribed with rheumatoid arthritis and pains in the lumbar separation during radiculitis.

Composition of the drug Ketorol

As an active substance of the tablet for form, Ketorolaca thrometamine acts, and the main auxiliary elements are: lactose, microcrystalline cellulose, corn starch.

The solution in ampoules is also based on ketorolac. But the auxiliary substances are different here: sodium chloride, ethyl alcohol, propylene glycol and okeoxinol. About 1 ml fall on purified water for injection.

The gel for outdoor use removes pain syndrome due to the same basic substance that is used in other dosage forms - ketorolac. Additional elements in the composition are observed: dimethyl sulfoxide, methyl aprichedroxibenzoate sodium, carbomer, thrometamine and water.

Pharmacological group

Ketorol refers to a group of non-steroidal anti-inflammatory drugs, which has many means of different composition, characterized by mechanisms of action, but similar pharmacological effects. The main difference between such a group is the lack of influence on the adrenal glands, that is, this group of medicines is not hormonal.

Three main directions in which non-steroidal anti-inflammatory funds operate:

Ketorol, being a representative of the NVPS, performs all three functions.

When Ketorol is prescribed

The three main directions of the drug form indications that become a reason for the purpose of Ketorol:

  • bruises of soft tissues;

  • bursitis;

  • damage to ligaments;

  • Sinovit;

  • Malgy any etiology;

  • neuralgia;

  • radiculitis;

  • rheumatism.

It should be remembered that the reception of ketorol is predominantly symptomatic. When pain appeared from the list of testimony - take the drug. In the absence of pain drinking ketorol or use the course in injections does not need.

The choice between tablets and injections is done after analyzing several factors:

  • If there are diseases of the stomach - pills are contraindicated;

  • With incessant vomiting or difficult swallowing, Ketorol is injected intramuscularly;

  • Fracture of jaws - the reason to make the choice is not in favor of the tablets;

  • Acute pain with radiculitis is removed faster after injection;

  • Menstrual pains are removed after taking the ketorol tablets;

  • The postoperative period also make the choice more often in favor of tablets, especially if intramuscular administration is complicated by the consequences of the operation.

Despite the fact that they are prescribed ketorol as NVPS, the main indication is pain. With increasing body temperature, preference is given to other actants.

Contraindications

Any nesteroid drugs, including ketorol, are not prescribed with the lesions of the gastrointestinal tract. This is due to the fact that the NVPS increase the risk of gastric bleeding, especially in people of 60+.

Other contraindications include:

In addition, simultaneous reception with the following medicines is prohibited:

Caution is taken by ketorol in diseases of the thyroid gland, diabetes and severe somatic diseases.

How to take Ketorol

With respect to the ingestion, two schemes differ in the type of tablets are used:

Pills for resorption contain 10 mg of active substance. When manifesting moderate pain is laying 1 tablet in the tongue to its complete dissolution. No water is not required. If the pain is returned after a while, you can repeat the reception. Maximum daily dose - 4 tablets (40 mg of ketorolac).

Tablets intended for swallowing with water contain 10 mg of ketorolaca. Daily reception should not exceed 40 mg of the drug. Adults can take ketorol in tablets every 4-6 hours. For the elderly patients of age category 60+, it is necessary to increase the interval between receptions up to 6-8 hours.

Injections for intramuscular administration can be repeated no more often than after 4 hours. The first anesthetic effect is noted after half an hour after the introduction of the solution. The maximum analgesic effect occurs after 1.5 hours.

Gel ketorol

The gel is applied locally to relieve pain caused by stupid injury or diseases of bones and joints. It is possible to use the gel only when there are no visible damage to the skin. Any abrasions, wounds and cuts are indisputable contraindications to the use of local agents.

Side Effects after receiving Ketorol

If the dosing mode is violated, the following side effects may be observed:

  • Disorders in the work of the digestive organs: nausea, heartburn, diarrhea.

  • Functioning system of urinary system: jade, renal failure, swelling, urination delay.

  • Violations in the work of the senses: ringing in ears, blurredness, violation of taste sensations (dullness of the sensitivity of receptors in the language).

  • Respiratory dysfunction: bronchospasm, rhinitis, shortness of breath, larynx swelling.

  • Problems with a cardiovascular system: an increase in blood pressure, a fainting condition.

  • Violations by the central nervous system: headaches, convulsions, hallucinations, muscle regions.

At the first signs of manifestation of any of the side symptoms, it is necessary to immediately stop using Ketorol and consult with the attending physician for the replacement of the drug.

The articular pain is a widespread symptom, which in one way or another feels about 80% of people over 35 years old. Cases can be naturally phenomenon, but when it bothers longer, with great intensity, look deeper than the problem.

Why do the joints hurt? Most frequent problems

Weettoral sensitivity, uncomfortable shoes, rapid growth of bones (teenagers are sick and knee joints) - the natural causes of the problem. This also includes senic defeat of joints and pregnancy.

List of diseases that illustrate illustrates "versatility" symptom:

  • Acute and chronic infections - ARVI, tract infections, flu, hymorite, tonsillitis, adnexitis;
  • Diseases associated with the destruction of the connective tissue (collagenosis) - rheumatism (the pain moves from the elbow joint to the ankles), arthritis, systemic sclerodermia;
  • osteoarthritis;
  • Violation of metabolism - osteoporosis (the hip joint is most of all), gout;
  • Oncology - osteomyelitis, osteosarcoma, chronic leukemia, lymphogranulomatosis;
  • injuries;
  • Reaction to medication.

In children, articular syndrome in combination with fever, rash, inflammation of the mucous membranes of the eyes and mouth can be a manifestation of heavy pathologies - still diseases, Kawasaki.

Symptoms of pain in the joints for taking action

How to distinguish natural discomfort from the symptom of a serious disease? Without a survey - in no way! You can endure pain for years and assume that it is "on the weather." It is wiser to make comprehensive diagnostics - blood tests, bakposev, sonography, CT. Spend a week of time, but learn the true cause of the articular pain. To drink painkillers is also not a solution. Write down to the doctor to arrange all the points on "i" and not run the process.

What to treat pain in the joints?

As a rule, with complaints about the joint syndrome, anti-inflammatory drugs are prescribed. They remove pain and temperature, contribute to the decrease in waste, but cause side disorders of the gastrointestinal tract, kidneys, blood systems. One of these means Sodium diclofenac

What medications take safely in the joints in the joints, the doctor will say. You can, of course, use the "international" means - Diclofenac But on the efficiency and duration of action there is a lot of other options:

Ointment and gels can not be applied to open wounds - it will only be worse. Before buying medications from the list above, consult the therapist. In any case, always read the annotation to the preparation.

Prevention with pains in the joints

The optimal version of the appearance of articular pain is an old age. If you encounter a problem earlier, pay attention to your nutrition and lifestyle. No need to buy dietary dietary supplements and vitamins, first consult with your doctor.

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